L. Maier

Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model

Baseline microbiome composition impacts resilience to and recovery following antibiotics

This study investigates how baseline gut microbiome composition affects resilience to and recovery from antibiotic treatment, identifying key taxa and functional modules associated with resilience.

An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens

NM102 targets the Mfd protein to reduce bacterial evolvability and treat infections caused by antibiotic-resistant Gram-negative bacteria.

Non-antibiotic drugs break colonization resistance against pathogenic Gammaproteobacteria

The paper tests non-antibiotic drugs' effects on gut microbiome composition and finds some increase Salmonella abundance, potentially increasing infection risk.

Emergence of community behaviors in the gut microbiota upon drug treatment

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

Consistency across multi-omics layers in a drug-perturbed gut microbial community

The paper examines consistency and complementarity across five omics layers in a drug-perturbed gut microbial community, finding high agreement in species abundance and functional insights from different data types.

Comparing the efficiency of six clearing methods in developing seeds of Arabidopsis thaliana

This study compares six clearing methods for Arabidopsis thaliana seeds, finding ClearSee alpha best preserves morphology and prevents tannin oxidation, while FAST9 offers faster clearing and better imaging.

Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response

This study shows that activating the Rcs phosphorelay in E. coli reduces growth rate and alters FtsZ distribution, with effects mediated through growth-rate changes rather than direct regulation.

Dissecting the collateral damage of antibiotics on gut microbes

This study characterizes the antibiotic activity spectrum on gut bacteria, revealing species-specific effects and identifying antidotes to mitigate collateral damage.

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

Microbiota stability in healthy individuals after single-dose lactulose challenge - a randomized controlled study

This study examines the effect of a single-dose lactulose challenge on gut microbiota stability and E. coli density in healthy individuals, finding no significant changes in E. coli levels or microbiota composition.