This study identifies a mechanism by which CD1c presents two lipids simultaneously, with bulky headgroups oriented sideways, enabling autoreactive TCR recognition.

Nature Communications · Dec 31, 2025Peer-reviewedImmunology

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue

Feng Liu, Hui Shi, Jason D. Turner, Rachel Anscombe, Jiaqi Li, Takuya Sekine, Ariane Hammitzsch, Devika Agarwal, Christopher B. Mahony, Jiewei Chen, Benjamin J. L. Kendrick, Dajiang Du, Qiang Tong, Lihua Duan, Kyla Dooley, , Liye Chen

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

Annals of the Rheumatic Diseases · May 23, 2025Peer-reviewedImmunology

Genomic and epidemiological analysis of SARS-CoV-2 viruses in Sri Lanka

Chandima Jeewandara, Deshni Jayathilaka, D.M.S.H.K. Ranasinghe, Sharon Nienyun Hsu, Dinuka Ariyaratne, Tibutius T. P. Jayadas, Deshan Madusanka, Benjamin B. Lindsey, Laksiri Gomes, Matthew D. Parker, Ananda Wijewickrama, Malika Karunaratne, Graham Stuart Ogg, Thushan I. de Silva, Gathsaurie Neelika Malavige

The paper analyzes SARS-CoV-2 genomic sequences from Sri Lanka to track lineage prevalence and transmission patterns, finding B.1.411 was dominant until B.1.1.7 replaced it in late 2020.

Frontiers in Microbiology · Sep 16, 2021Peer-reviewedGenetic & Genomic Medicine

Addressing differentiation in live human keratinocytes by assessment of membrane packing order

Danuta Gutowska‐Owsiak, Ewa Izabela Podobas, Christian Eggeling, Graham Stuart Ogg, Jorge Bernardino de la Serna

This study develops a live-cell method to assess keratinocyte differentiation using membrane packing order as a marker, applicable at single-cell and high-throughput levels.

Frontiers in Cell and Developmental Biology · Oct 21, 2020Peer-reviewedDevelopmental Biology