Author

James J. Fink

Q-State Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:electronic health records· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Eric S. LevineiD· 2 shared Judy E. Bloom· 2 shared Stormy J. ChamberlainiD· 2 shared Adrian Peter BirdiD· 1 shared Amy E. Elder· 1 shared Brenda Murage· 1 shared Caitlin L. LewarchiD· 1 shared Carissa L. SiroisiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersGenetics

Eric S. LevineORCID

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Author profile →

4 papers

Recent·Most cited

Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis

Luis A. Williams, Steven J. Ryan, Vaibhav Joshi, Caitlin L. Lewarch, Amy E. Elder, Owen B. McManus, Patrice Godard, Srinidhi Sridhar, Jane Jacques, Jennifer Grooms, James J. Fink, Hongkang Zhang, Michel R. Gillard, Cécile Pégurier, Yogesh A. Sabnis, , Graham T. Dempsey

The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.

bioRxiv · Feb 22, 2024 · PreprintNeuroscience

Convergent Cerebrospinal Fluid Proteomes and Metabolic Ontologies in Humans and Animal Models of Rett Syndrome

Stephanie A. Zlatic, Duc Minh Duong, Kamal K.E. Gadalla, Brenda Murage, Lingyan Ping, Ruth Shah, James J. Fink, Omar Khwaja, Lindsay C. Swanson, Mustafa Şahin, Sruti Rayaprolu, Prateek Kumar, Srikant Rangaraju, Adrian Peter Bird, Daniel Charles Tarquinio, , Victor Faúndez

The paper identifies shared proteomic and metabolic ontologies in Rett syndrome across species and validates them as potential biomarkers.

iScience · Aug 17, 2022Peer-reviewedNeuroscience

Abundance and localization of human UBE3A protein isoforms

Carissa L. Sirois, Judy E. Bloom, James J. Fink, Dea Gorka, Steffen Johannes Keller, Noélle D. Germain, Eric S. Levine, Stormy J. Chamberlain

The paper investigates the abundance and localization of human UBE3A protein isoforms and their impact on Angelman Syndrome phenotypes using CRISPR/Cas9-generated isogenic cells.

Human Molecular Genetics · Aug 18, 2020Peer-reviewedGenetics

Hyperexcitable phenotypes in iPSC-derived neurons from patients with 15q11-q13 duplication syndrome, a genetic form of autism

James J. Fink, Jeremy D. Schreiner, Judy E. Bloom, Jadin James, Dylan S. Baker, Tiwanna M. Robinson, Richard Lieberman, Leslie M. Loew, Stormy J. Chamberlain, Eric S. Levine

This study investigates hyperexcitability in iPSC-derived neurons from Dup15q patients, identifying mechanisms like delayed action potential maturation and KCNQ2 channel disruption.

bioRxiv · Mar 21, 2018Neuroscience