Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis
Luis A. Williams, Steven J. Ryan, Vaibhav Joshi, Caitlin L. Lewarch, Amy E. Elder, Owen B. McManus, Patrice Godard, Srinidhi Sridhar, Jane Jacques, Jennifer Grooms, James J. Fink, Hongkang Zhang, Michel R. Gillard, Cécile Pégurier, Yogesh A. Sabnis, , Graham T. Dempsey
The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.
bioRxiv · Feb 22, 2024 · PreprintNeuroscience