Antibodies, Memory B Cells, and Antigen Valency Reshape B Cell Responses to Drifted Influenza Virus Vaccination
Laura Reusch, Nimitha R. Mathew, Karin Schön, Ivan Košík, James S. Gibbs, Madeleine C. Mankowski, Danica F. Besavilla, Jonathan Wilson Yewdell, Mats Bemark, Davide Angeletti
This study investigates how vaccine antigen valency and pre-existing memory B cells influence B cell responses to drifted influenza virus, showing differential effects on germinal center dynamics and immunodominance.
bioRxiv · Nov 7, 2025 · PreprintImmunology