Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent S-Nitroso Transfer
Aaron Issaian, Monika Dzieciątkowska, Shaun G. Bevers, Zohreh Safari, Ariel M. Hay, Anthony J. Saviola, Jasmina S. Redzic, Julie A. Reisz, Gregory R. Keele, Francesca Isabelle Cendali, Zachary B. Haiman, Travis G. Nemkov, Daniel Stephenson, Christina Lisk, Francesca Vallese, , Angelo D’Alessandro
The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.
bioRxiv · Nov 29, 2025 · PreprintBiochemistry