Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM
Jorge L. Jimenez-Macias, Philippa C. Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan E. Forrest, Jason S. Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William M. Hawkins, Noe B. Mercado, Jacqueline Real, Kelsey E. Huntington, Mykola I. Zdioruk, Michal Oskar Nowicki, , Sean Edward Lawler
This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.
Science Advances · Feb 26, 2025Peer-reviewedCancer Biology