Author

Zheyun Xu

Brown UniversityORCID 0000-0002-1101-7014Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alexander S. BrodskyiD· 1 shared Andrea SchmidtiD· 1 shared Ayush BharatiiD· 1 shared Bin WuiD· 1 shared Bogdan I. FedelesiD· 1 shared Choi‐Fong ChoiD· 1 shared Jacqueline Real· 1 shared Jasmine Clark· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander S. BrodskyORCID

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1 paper

Recent·Most cited

Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM

Jorge L. Jimenez-Macias, Philippa C. Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan E. Forrest, Jason S. Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William M. Hawkins, Noe B. Mercado, Jacqueline Real, Kelsey E. Huntington, Mykola I. Zdioruk, Michal Oskar Nowicki, , Sean Edward Lawler

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

Science Advances · Feb 26, 2025Peer-reviewedCancer Biology