Jennifer Okamoto

Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV

The paper uses cfDNA/cfRNA sequencing to identify molecular correlates of bNAb development in HIV patients, finding an MHC class I activation signature and microbial changes associated with bNAb production.

Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism

The paper creates a comprehensive cell atlas of mouse lemurs using single-cell RNA sequencing, identifying over 750 cell types and comparing their molecular profiles to humans, mice, and macaques.

Molecular and Morphological Signatures of Chordate Development: Two Distinct Pathways, One Tunicate

This study compares molecular and morphological signatures in two developmental pathways of tunicates, finding distinct molecular programs but shared stem cell profiles.

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing

This study uses scRNA-seq to analyze microglia and myeloid cells across brain regions and developmental stages, revealing heterogeneity in postnatal microglia and their roles in disease.

Evolutionary Origin of the Mammalian Hematopoietic System Found in a Colonial Chordate

The paper identifies hematopoietic stem cells and related lineages in Botryllus schlosseri, suggesting their evolutionary origin in a common ancestor of tunicates and vertebrates.

A Noninvasive Molecular Clock for Fetal Development Predicts Gestational Age and Preterm Delivery

This study uses cell-free RNA from blood samples to create a molecular clock for fetal development, predicting gestational age and preterm delivery risk.