Stephanie Lozano

Precocious maturation and Purkinje cell dysfunction in the mouse Chd8 haploinsufficient cerebellum

This study examines the effects of Chd8 haploinsufficiency on cerebellar development and function in mice, revealing cell-type-specific transcriptomic and physiological changes.

Molecular interactions of Chd8 in mouse brain highlights a role in chromatin-associated RNA processing

The paper identifies CHD8 interactions in mouse brain, revealing a role in chromatin-associated RNA processing and highlighting dosage sensitivity in neurodevelopmental disorders.

Global impact of aberrant splicing on human gene expression levels

The paper estimates the impact of alternative splicing coupled with nonsense-mediated decay on gene expression levels using population-scale genomic data and perturbation experiments.

A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation

This study identifies a Hedgehog-FGF signaling axis critical for anterior mesoderm patterning during gastrulation using single-cell transcriptomics in Hh-deficient embryos.

Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation

The paper compares Drop-seq and DroNc-seq in profiling cardiomyocyte differentiation, finding similar cell types and trajectories in both methods.