Author

Jonathan S. Paw

Calico Life Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:database / resource· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Cynthia J. KenyoniD· 2 shared Ainhoa Etxeberría· 1 shared Andrew G. York· 1 shared Antoine E. RouxiD· 1 shared Brad A. FriedmaniD· 1 shared Catherine S. SharpiD· 1 shared Chunlian ZhangiD· 1 shared David V. Hansen· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersSystems Biology

Cynthia J. KenyonORCID

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Author profile →

3 papers

Recent·Most cited

Partial reprogramming restores youthful gene expression through transient suppression of cell identity

Antoine E. Roux, Chunlian Zhang, Jonathan S. Paw, Jose Zavala‐Solorio, Evangelia Malahias, Twaritha Vijay, Ganesh A. Kolumam, Cynthia J. Kenyon, Jacob C. Kimmel

This study investigates how transient reprogramming affects somatic cell identity and aging in mice, finding that it can restore youthful gene expression but also suppress identity programs.

Cell Systems · Jun 10, 2022Peer-reviewedSystems Biology

Split-wrmScarlet and split-sfGFP: Tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans

Jerome F Goudeau, Catherine S. Sharp, Jonathan S. Paw, Laura Savy, Manuel D. Leonetti, Andrew G. York, Dustin L. Updike, Cynthia J. Kenyon, Maria Ingaramo

The paper introduces split-wrmScarlet and split-sfGFP tools for faster fluorescent labeling of endogenous C. elegans proteins using CRISPR.

Genetics · Feb 2, 2021Peer-reviewedGenetics

Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation

Karpagam Srinivasan, Brad A. Friedman, Ainhoa Etxeberría, Melanie A. Huntley, Marcel P. van der Brug, Oded Foreman, Jonathan S. Paw, Zora D. Modrusan, Thomas G. Beach, Geidy E. Serrano, David V. Hansen

The paper identifies a novel transcriptional signature in human Alzheimer's myeloid cells that differs from mouse models and shows aging-related and AD-specific gene expression changes.

Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience