Dustin L. Updike

C. elegans nucleolar RG repeats are sufficient for nucleolar accumulation but insufficient for sub-nucleolar compartmentalization

This study shows that RG repeats in C. elegans can accumulate in nucleoli but not form specific sub-nucleolar compartments.

Two germ granule eIF4E isoforms reside in different mRNPs to hand off C elegans mRNAs from translational repression to activation

The paper identifies two eIF4E isoforms in C. elegans germ granules that regulate mRNA translation by sequentially repressing and activating germline mRNAs.

The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline

The paper identifies LOTR-1, a C. elegans protein with LOTUS and Tudor domains, which interacts with ZNFX-1 to regulate small RNA processing in the germline.

Split-wrmScarlet and split-sfGFP: Tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans

The paper introduces split-wrmScarlet and split-sfGFP tools for faster fluorescent labeling of endogenous C. elegans proteins using CRISPR.

Germline maintenance through the multifaceted activities of GLH/Vasa in Caenorhabditis elegans P granules

The paper investigates the role of GLH-1/Vasa helicase domains in C. elegans germ granules, showing their necessity for granule association and their interaction with Argonaute proteins and PCI scaffolding complexes.