Conserved programs and specificities of T cells targeting hematological malignancies
Tim R. Wagner, Niklas Kehl, Simon Steiger, Tamara Boschert, Michael Kilian, Kane A. Foster, Gabrielle M. Hernandez, Claudia Ctortecka, Julius Michel, Antonia Schach, Julian Zoller, Anna D. Metzler, René Onken, Bruno Schönfelder, Simon Renders, , Mirco Friedrich
This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.
bioRxiv · Aug 7, 2025 · PreprintImmunology