Author

K. Chew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:mouse· 1

Frequent Co-Authors

A. Ozonoff· 2 shared D. J. Dowling· 2 shared E. Nanishi· 2 shared M. De Leon· 2 shared O. Levy· 2 shared S. Dhe-Paganon· 2 shared T. R. O'Meara· 2 shared A. Burke· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. Ozonoff

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Author profile →

3 papers

Recent·Most cited

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

K. Chew, B. Lee, S. Van Haren, E. Nanishi, T. R. O'Meara, J. B. Splaine, M. De Leon, D. Soni, H.-S. R. Seo, S. Dhe-Paganon, A. Ozonoff, J. A. Smith, O. Levy, D. J. Dowling

This paper describes a high-throughput screening method using human PBMCs to identify adjuvant candidates, resulting in a lead compound with in vivo adjuvanticity.

bioRxiv · Jun 17, 2022 · PreprintImmunology

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2

S. Swaminathan, K. Lineburg, G. Ambalathingal, P. Crooks, E. Grant, S. Mohan, J. Raju, A. Panikkar, L. Le Texier, Z. Tong, K. Chew, M. Neller, H. Gowda, K. Short, S. Gras, , R. Khanna

The paper identifies conserved T-cell epitopes in SARS-CoV-2 and finds that immune responses against them are subdominant due to low antigen abundance.

bioRxiv · Oct 13, 2021 · PreprintImmunology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology