Author

D. J. Dowling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Assay:flow cytometry· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

O. Levy· 6 shared E. Nanishi· 5 shared S. Dhe-Paganon· 4 shared A. Ozonoff· 3 shared C. Dillen· 3 shared F. Borriello· 3 shared H.-S. Seo· 3 shared M. De Leon· 3 shared

Activity by Year

2019-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

O. Levy

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8 papers

Recent·Most cited

Deep phenomics of African green monkey and Baboon PBMCs using a 30-marker spectral flow cytometry panel

Soumik Barman, A. Patel, M. J. Buonopane, B. Janoschek, R. Hingorani, D. J. Dowling

The paper develops a 30-marker spectral flow cytometry panel to profile immune cell subsets in African green monkey and baboon PBMCs, focusing on T cell subsets, cytokines, and activation markers.

bioRxiv · Nov 9, 2026 · PreprintImmunology

Immune-profiling of T helper 1 (Th1), Th2 and Th17 signatures in murine splenocytes by targeting intracellular cytokines

S. Barman, A. Kelly, D. Dong, A. Patel, M. J. Buonopane, J. Gonzales, B. Janoschek, A. Draghi, D. J. Dowling

The paper develops a 17-parameter spectral flow cytometry panel to profile Th1, Th2, and Th17 cytokine signatures in murine splenocytes under steady-state and stimulated conditions.

Cytometry Part A · Mar 17, 2025Peer-reviewedImmunology

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

T. R. O'Meara, E. Nanishi, M. E. McGrath, S. Barman, D. Dong, C. Dillen, M. Menon, H.-S. Seo, S. Dhe-Paganon, R. K. Ernst, O. Levy, M. B. Frieman, D. J. Dowling

bioRxiv · Dec 7, 2022Immunology

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

K. Chew, B. Lee, S. Van Haren, E. Nanishi, T. R. O'Meara, J. B. Splaine, M. De Leon, D. Soni, H.-S. R. Seo, S. Dhe-Paganon, A. Ozonoff, J. A. Smith, O. Levy, D. J. Dowling

This paper describes a high-throughput screening method using human PBMCs to identify adjuvant candidates, resulting in a lead compound with in vivo adjuvanticity.

bioRxiv · Jun 17, 2022 · PreprintImmunology

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

S. Barman, F. Borriello, B. Brook, C. Pietrasanta, M. De Leon, C. Sweitzer, M. Menon, S. D. van Haren, D. Soni, Y. Saito, E. Nanishi, S. Yi, S. Bobbala, O. Levy, E. A. Scott, D. J. Dowling

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

bioRxiv · Jun 3, 2022Immunology

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

F. Borriello, E. Nanishi, H.-S. Seo, T. R. OMeara, M. E. McGrath, Y. Saito, R. E. Haupt, J. Chen, J. Diray-Arce, K. Song, A. Z. Xu, T. M. Caradonna, J. Feldman, B. M. Hauser, A. G. Schmidt, , O. Levy

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

bioRxiv · Sep 9, 2021 · PreprintImmunology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology

The TLR5 agonist flagellin modifies phenotypical and enhances functional activation of lung mucosal antigen presenting cells in neonatal mice

P. Sharma, O. Levy, D. J. Dowling

This study shows that flagellin activates neonatal lung APCs more effectively than other PRR agonists, suggesting its potential as an adjuvant for early life mucosal vaccines.

bioRxiv · Mar 11, 2019Immunology