R. Weber

Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium

This study shows that mTORC2 and dietary potassium coordinate renal glucose reabsorption and gluconeogenesis through independent mechanisms, with implications for diabetes management.

Human DDX6 regulates translation and decay of inefficiently translated mRNAs

This study shows DDX6 regulates decay of inefficiently translated mRNAs by interacting with ribosomes and requiring ATPase activity.

Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells

This study uses CRISPRoff to introduce site-specific CpG methylation in the MGMT promoter of glioblastoma cells, showing reduced MGMT expression and increased temozolomide sensitivity.

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

This study shows that Apold1 is not essential for normal angiogenesis but is critical for revascularization under ischemic conditions and tumor growth.

In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer

This study uses in vivo CRISPR screens to identify USP15 and SCAF1 as novel tumor suppressors in pancreatic cancer, with potential therapeutic implications.

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

This study identifies SLC25A39 as a mitochondrial glutathione importer and shows its role in cell proliferation and red blood cell development, with GSH availability regulating its abundance.

Monitoring the 5`UTR landscape reveals 5`terminal oligopyrimidine (TOP) motif switches to drive translational efficiencies

The paper uses long-read sequencing to analyze 5'UTR isoforms in epidermal stem cells and squamous cell carcinomas, showing TOP motif switches affect translational efficiency.

The Role of ATP in the RNA Translocation Mechanism of SARS-CoV-2 NSP13 Helicase

This paper models SARS-CoV-2 nsp13 helicase in different substrate states to elucidate its ATP-dependent RNA translocation mechanism using molecular dynamics simulations and structural clustering.

Measurement of Volatile Compounds for Real-time Analysis of Soil Microbial Metabolic Response to Simulated Snowmelt

This study uses PTR-TOF-MS to analyze microbial volatile compounds during simulated snowmelt, revealing metabolic responses and interactions in soil microbiomes.

Failure of VITEK2 to reliably detect vanB- mediated vancomycin resistance in Enterococcus faecium

This study shows VITEK2 fails to reliably detect vanB-mediated vancomycin resistance in Enterococcus faecium, leading to potential treatment failures.

Multicenter Analysis of Dosing Protocols for Sotalol Initiation

This study analyzes dosing protocols for sotalol initiation in 213 patients, finding that dose adjustment predicts successful initiation, with several clinical factors associated with the need for adjustment.

Applications of Machine Learning in Decision Analysis for Dose Management for Dofetilide

This study uses machine learning to analyze dose adjustment decisions for dofetilide, finding that reinforcement learning identifies patient characteristics and dosing decisions that minimize discharge failure.