K. Ho

In Utero Hematopoietic Stem Cell Transplant for Fanconi Anemia

This study demonstrates that in utero hematopoietic stem cell transplantation (HSCT) without conditioning can effectively engraft donor cells in FA mouse models, achieving high donor chimerism and potentially offering a safe prenatal treatment for FA.

Docking interactions determine substrate specificity of members of a widespread family of protein phosphatases

The paper identifies a conserved substrate docking interface in PPM phosphatases that determines substrate specificity through allosteric regulation.

A General Mechanism for Initiating the General Stress Response in Bacteria

The paper identifies a coiled-coil linker mechanism in RsbU that activates the General Stress Response in bacteria by transducing signals from sensor domains.

Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

The paper shows efflux promotes antibiotic resistance mutations by linking high efflux to reduced DNA repair, validated through a clinical resistome database and swarm experiments.

Interpretable multimodal deep learning for real-time pan-tissue pan-disease pathology search on social media

The paper develops interpretable deep learning models to search for similar disease states across social media and PubMed using histopathology images and clinical data, achieving high precision in real-time diagnosis assistance.

A conserved regulatory switch controls phosphatase activity and specificity

The paper identifies a conserved regulatory switch in PP2C phosphatases that controls activity and substrate specificity through metal cofactor binding and regulatory input integration.

Loss of function mutations in epaR confer resistance to phage NPV1 infection in Enterococcus faecalis OG1RF

This study identifies loss-of-function mutations in epaR as conferring resistance to phage NPV1 in E. faecalis OG1RF by blocking phage adsorption, but these mutations also increase susceptibility to daptomycin and osmotic stress.