Author

K. K. Ewert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. R. Safinya· 4 shared V. M. Steffes· 4 shared W. S. Fisher· 2 shared Y. Li· 2 shared J. Crowe· 1 shared L. Simon-Gracia· 1 shared M. Murali· 1 shared P. D. Scodeller· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiophysics

C. R. Safinya

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4 papers

Recent·Most cited

Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes

V. M. Steffes, S. MacDonald, J. Crowe, M. Murali, K. K. Ewert, Y. Li, C. R. Safinya

This study shows that lipids with negative spontaneous curvature, like DOPE and GMO, reduce paclitaxel solubility in liposomes, making them unsuitable for drug delivery.

bioRxiv · Oct 18, 2023Biophysics

The Influence of Multivalent Charge and PEGylation on Shape Transitions in Fluid Lipid Assemblies: From Vesicles to Discs, Rods, and Spheres

V. M. Steffes, Z. Zhang, K. K. Ewert, C. R. Safinya

This study investigates how multivalent cationic lipid MVL5 and PEG-lipids affect the structure of fluid lipid assemblies, revealing distinct morphologies like discs, rods, and spheres.

bioRxiv · Aug 9, 2023 · PreprintBiophysics

Paclitaxel-loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation

L. Simon-Gracia, P. D. Scodeller, W. S. Fisher, V. Sidorenko, V. M. Steffes, K. K. Ewert, C. R. Safinya, T. Teesalu

This study shows that increasing PEG coverage on cationic lipid nanoparticles improves their tumor penetration and proapoptotic activity when delivering paclitaxel.

bioRxiv · Mar 28, 2022Biophysics

Enhanced Loading of Paclitaxel in Cationic Liposomes by Replacement of Oleoyl with Linoleoyl Lipid Tails with Benefits in Cancer Therapeutics from In Vitro Studies

Y. Zhen, K. K. Ewert, W. S. Fisher, V. M. Steffes, Y. Li, C. R. Safinya

This study shows that replacing oleoyl with linoleoyl lipid tails in cationic liposomes increases paclitaxel solubility, enhancing cancer therapeutic efficacy without increasing toxicity.

bioRxiv · Oct 12, 2020Biophysics