Y. Zhen

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

De novo genome assembly of Myricaria laxiflora provides insights into its molecular mechanisms under flooding stress

This study assembles the first high-quality genome of M. laxiflora and identifies AP2/ERF genes involved in flooding stress response.

Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistancestrategies.

This study shows that predatory fireflies and their toxic prey have evolved distinct toxin resistance strategies through gene duplication and neofunctionalization.

Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors

This study identifies RNF114 as a key player in PARP1 trapping and shows that nimbolide blocks its degradation, enhancing PARP1 trapping and cytotoxicity in BRCA-deficient cancers.

Histone neutralization in a rat model of acute lung injury induced by double-hit lipopolysaccharide

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

Enhanced Loading of Paclitaxel in Cationic Liposomes by Replacement of Oleoyl with Linoleoyl Lipid Tails with Benefits in Cancer Therapeutics from In Vitro Studies

This study shows that replacing oleoyl with linoleoyl lipid tails in cationic liposomes increases paclitaxel solubility, enhancing cancer therapeutic efficacy without increasing toxicity.

Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared to mice and Drosophila melanogaster

The paper estimates higher proportions of beneficial mutations and stronger selection in humans compared to mice and Drosophila melanogaster, suggesting organismal complexity influences adaptive evolution.

PacBio SMRT-based full-length transcriptome data of Ascosphaera apis mycelium and spore

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

The phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors

The paper identifies PTPRG as a phosphatase that dephosphorylates FGFR1, enhancing FGFR inhibitor sensitivity in osteosarcoma cells.