Author

L. Simon-Gracia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. Teesalu· 5 shared A. D. Davidson· 2 shared B. Simonetti· 2 shared C. R. Safinya· 2 shared D. K. Shoemark· 2 shared J. L. Daly· 2 shared K. Klein· 2 shared P. J. Cullen· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBiophysics

T. Teesalu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Paclitaxel-loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation

L. Simon-Gracia, P. D. Scodeller, W. S. Fisher, V. Sidorenko, V. M. Steffes, K. K. Ewert, C. R. Safinya, T. Teesalu

This study shows that increasing PEG coverage on cationic lipid nanoparticles improves their tumor penetration and proapoptotic activity when delivering paclitaxel.

bioRxiv · Mar 28, 2022Biophysics

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

B. Simonetti, J. L. Daly, L. Simon-Gracia, K. Klein, S. Weeratunga, C. Anton-Plagaro, A. Tobi, L. Hodgson, P. Lewis, K. J. Heesom, D. K. Shoemark, A. D. Davidson, B. M. Collins, T. Teesalu, Y. Yamauchi, P. J. Cullen

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

bioRxiv · Jan 20, 2022Cell Biology

Neuropilin-1 is a host factor for SARS-CoV-2 infection

J. L. Daly, B. Simonetti, C. Anton Plagaro, M. Kavanagh Williamson, D. K. Shoemark, L. Simon-Gracia, K. Klein, M. Bauer, R. Hollandi, U. F. Greber, P. Horvath, R. B. Sessions, A. Helenius, J. A. Hiscox, T. Teesalu, , Y. Yamauchi

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

bioRxiv · Jun 5, 2020Cell Biology

Application of Polymersomes Engineered to Target P32 Protein for Detection of Small Breast Tumors in Mice

L. Simon-Gracia, P. Scodeller, S. Salzar Fuentes, V. Gomez Vallejo, X. Rios, E. San Sebastian, V. Sidorenko, D. Di Silvio, M. Suck, F. De Lorenzi, L. Yokota Rizzo, S. von Stillfried, K. Kilk, T. Lammers, S. E. Moya, T. Teesalu

This study uses p32-targeted polymersomes for PET imaging of small TNBC tumors in mice, showing enhanced accumulation and detection capability.

bioRxiv · Feb 19, 2018Cancer Biology

Competition of Charge-Mediated and Specific Binding by Peptide-Tagged Cationic Liposome-DNA Nanoparticles In Vitro and In Vivo

E. Wonder, L. Simon-Gracia, P. Scodeller, R. N. Majzoub, V. R. Kotamraju, K. Ewert, T. Teesalu, C. R. Safinya

This study investigates how peptide density and charge affect the binding and uptake of cationic liposome-DNA nanoparticles by cancer cells and evaluates their tumor selectivity in vivo.

bioRxiv · Dec 20, 2017Biophysics