j. yewdell

Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice

This study shows that pre-existing antibodies inhibit de novo B cell responses to influenza antigens in mice, but not to other vaccine antigens.

C1q Enables Influenza HA Stem Binding Antibodies to Block Viral Attachment and Broadens the Antibody Escape Repertoire

This study shows that C1q enhances anti-hemagglutinin stem antibody neutralization by blocking viral attachment and expanding the viral escape repertoire.

Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

This study shows Omicron SARS-CoV-2 has higher infectivity and interferon resistance in human nasal tissue compared to Delta, due to changes in Spike protein entry mechanisms.

Paradox Found: Global Accounting of Lymphocyte Protein Synthesis

The paper measures protein synthesis rates in lymphocytes and finds that their in vivo elongation rates increase with activation, despite a high protein-to-ribosome ratio suggesting insufficient capacity for rapid division.

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

The paper validates in vitro human lung tissue models for studying SARS-CoV-2 and influenza virus infections and antiviral treatments.

Influenza A Virus Negative Strand RNA is Translated for CD8+ T Cell Immunosurveillance

This study shows that influenza A virus negative strand RNA can be translated into proteins recognized by CD8+ T cells, challenging the notion that viral negative strands are non-coding.