N. Saito

Evolution of hierarchy and irreversibility in theoretical cell differentiation model

This study shows that hierarchy and irreversibility in cell differentiation emerge naturally in a mathematical model as the number of terminal states increases, without requiring adaptive selection.

A model explaining environmental stiffness-dependent migration of fibroblasts with a focus on maturation of intracellular structures

The paper develops a mathematical model to explain how fibroblast migration velocity depends on substrate stiffness through changes in stress fiber maturation and contractile force.

Establishment of Measles Virus Receptor-expressing Vero Cells Lacking Functional Poliovirus Receptors

The paper establishes PV-non-susceptible Vero cell lines for isolating measles and rubella viruses without PV replication risk.

Microbial Potlatch: Cell-level adaptation of leakiness of metabolites leads to resilient symbiosis among diverse cells

The paper shows that microbial cells evolve to leak essential metabolites, enabling mutualistic coexistence with consumer cells and leading to resilient, diverse ecosystems.

Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space

The paper maps crawling-cell morphodynamics in a deep learning-based feature space using phase-field modeling and identifies key parameters for migratory morphologies under perturbations.

Micro-topographical guidance of macropinocytic signaling patches

The paper shows that micro-topography guides macropinocytic signaling patches in Dictyostelium, with PI3K-dependent nucleation and confinement at convex and concave surfaces, respectively.

Three-dimensional morphodynamics simulations of macropinocytic cups

This study develops a computational framework to simulate macropinocytic cup formation, showing that protrusive forces from signaling patches can create self-enclosing structures without external support.

Rac-dependent signaling from keratinocytes promotes differentiation of intradermal white adipocytes

This study shows that Rac-dependent signaling from keratinocytes promotes white and brown adipocyte differentiation through paracrine BMP2 and FGF21 pathways.