S. R. Collins

Cell migration CRISPRi screens in human neutrophils reveal regulators of context-dependent migration and differentiation state

The paper uses CRISPRi screens in human neutrophils to identify genes regulating context-dependent migration and differentiation.

Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.

This study predicts microbiota responses to environmental pH and osmolality by analyzing bacterial growth under controlled conditions and identifying predictive genes and pathways.

Signaling dynamics distinguish high and low priority neutrophil attractant receptors

The paper shows that high and low priority neutrophil attractants elicit distinct signaling dynamics, with high priority signals being sustained and low priority signals being transient.

Mechanical competition promotes selective listening to receptor inputs to resolve directional dilemmas in neutrophil migration

This study shows neutrophils resolve directional dilemmas by committing to one leading edge late in the decision process, influenced by mechanical stretching and receptor inputs.

Wnt/PCP signaling mediates breast cancer metastasis by promoting pro-invasive protrusion formation in collectively motile leader cells

This study shows Wnt/PCP signaling promotes breast cancer metastasis by enhancing pro-invasive protrusions in leader cells during collective migration.

WASP integrates substrate topology and cell polarity to guide neutrophil migration

This study shows WASP integrates substrate topology and cell polarity to guide neutrophil migration by selectively polymerizing actin at the leading edge.

Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing

The paper uses optogenetic tools to show that F-actin and Cdc42 provide distinct negative signals that limit Cdc42 activation during chemotaxis.

Optimized iLID membrane anchors for local optogenetic protein recruitment

This paper improves the iLID optogenetic system by optimizing membrane anchors to enhance local protein recruitment and spatial precision.