Author

K. Melcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

H. E. Xu· 2 shared P. W. de Waal· 2 shared X. Wang· 2 shared Y. Jiang· 2 shared B. Dickson· 1 shared B. O. Williams· 1 shared C. R. Diegel· 1 shared E. You· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

H. E. Xu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Generation of a New Frizzled 2 Flox Mouse Model to Clarify Its Role in Development

M. N. Michalski, C. R. Diegel, Z. A. Zhong, K. Suino-Powell, L. Blazer, J. Adams, VAI Vivarium and Transgenics Core, I. Beddows, K. Melcher, S. S. Sidhu, S. Angers, B. O. Williams

The paper generates a new Fzd2 flox mouse model to investigate tissue-specific roles of Fzd2, resolving contradictions in previous global knockout studies.

bioRxiv · Jan 27, 2021 · PreprintCell Biology

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

P. W. de Waal, J. Shi, E. You, X. Wang, K. Melcher, Y. Jiang, H. E. Xu, B. Dickson

This paper investigates how fentanyl activates the mu-opioid receptor through beta-arrestin biased signaling using molecular dynamics simulations and validates findings with synthesized compounds.

PLOS Computational Biology · Apr 10, 2020Peer-reviewedBiophysics

A complex structure of arrestin-2 bound to a G protein-coupled receptor

W. Yin, Z. Li, M. Jin, Y. Yin, P. W. de Waal, K. Pal, Y. Yin, X. Gao, Y. He, J. Gao, X. Wang, Y. Zhang, H. Zhou, K. Melcher, Y. Jiang, , H. E. Xu

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

bioRxiv · Oct 29, 2019Biophysics