J. E. Bisanz

Microbiome single cell atlases generated with a commercial instrument

The paper introduces EASi-seq, a method for single-cell sequencing of microbes using a commercial platform, enabling detailed microbiome atlases and improved bioinformatic analysis.

Mild SARS-CoV-2 infection results in long-lasting microbiota instability

This study shows that mild SARS-CoV-2 infection causes long-term gut microbiota instability in both humans and mice, with Omicron variant also disrupting microbial communities despite causing milder symptoms.

Systems biology illuminates alternative metabolic niches in the human gut microbiome

This study identifies the metabolic niche of Eggerthella lenta in the human gut by combining experimental and computational approaches, revealing its use of acetate and arginine catabolism.

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

This study uses phage-delivered CRISPR-Cas9 to deplete specific E. coli strains and induce genomic deletions in the gut microbiome of mice.

Human gut bacteria produce TH17-modulating bile acid metabolites

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic health

The paper compares gut microbiomes of East Asian and White individuals in the same geographic area, finding ethnic differences linked to metabolic health and independent of diet.

Diet induces reproducible alterations in the mouse and human gut microbiome

This study identifies reproducible gut microbiome changes induced by a high-fat diet in mice and shows that a machine learning model can predict dietary intake in mice and humans.