Author

K. R. Liedl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 2 Cell Biology· 1 Physiology· 1

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Assay:electrophysiology· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. S. Kamenik· 2 shared B. E. Flucher· 2 shared M. L. Fernandez-Quintero· 2 shared A. B. Ward· 1 shared A. L. Kochiss· 1 shared B. K. Shoichet· 1 shared B. Sarg· 1 shared C. Briganser· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersBiophysics

A. S. Kamenik

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi

Y. Weyer, S. I. Schwabl, X. Tang, M. A. Widerin, V. Niedrist, M. G. Tettamanti, S. Weys, B. Sarg, L. Kremser, K. R. Liedl, O. Schmidt, D. Teis

This study identifies the Dsc ubiquitin ligase complex as a quality control mechanism at the Golgi that degrades orphaned proteins by assessing transmembrane domain hydrophobicity.

bioRxiv · Mar 11, 2024Cell Biology

Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of CaV1.3 Channels

P. J. del Rivero Morfin, A. L. Kochiss, K. R. Liedl, B. E. Flucher, M. L. I. Fernandez-Quintero, M. Ben-Johny

The paper investigates how asymmetric conformational changes in CaV1.3 channels mediate voltage- and calcium-dependent inactivation through distinct molecular mechanisms.

bioRxiv · Sep 21, 2023Biophysics

PEP-Patch: Electrostatics in Protein-Protein Recognition, Specificity and Antibody Developability

F. Waibl, N. D. Pomarici, V. J. Hoerschinger, J. R. Loeffler, C. Deane, G. Georges, H. Kettenberger, M. L. Fernandez-Quintero, K. R. Liedl

PEP-Patch quantifies and visualizes protein electrostatic potential to analyze protease specificity, antibody-antigen recognition, and predict antibody pharmacokinetics.

bioRxiv · Jul 14, 2023 · PreprintBiophysics

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

G. Martin, M. L. Fernandez Quintero, W.-H. Lee, T. Pholcharee, L. Eshun-Wilson, K. R. Liedl, M. Pancera, R. A. Seder, I. A. Wilson, A. B. Ward

The paper determines the cryo-EM structure of the anti-PfCSP antibody L9, revealing its multivalent binding to NPNV repeats and the role of the light chain in affinity and protective efficacy.

bioRxiv · Oct 7, 2022 · PreprintImmunology

Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1

Y. E. El Ghaleb, N. J. Ortner, W. Posch, M. L. Fernandez-Quintero, W. E. Tuinte, S. Monteleone, H. J. Draheim, K. R. Liedl, D. Wilflingseder, J. Striessnig, P. Tuluc, B. E. Flucher, M. Campiglio

This study shows that the γ1 subunit reduces current density of CaV1.1a but not CaV1.1e, and this effect depends on alternative splicing of exon 29 in CaV1.1a.

bioRxiv · Nov 10, 2021 · PreprintPhysiology

Energy Penalties Enhance Flexible Receptor Docking in a Model Cavity

A. S. Kamenik, I. Singh, P. Lak, T. E. Balius, K. R. Liedl, B. K. Shoichet

The paper tests flexible receptor docking with energy penalties using MD simulations on T4 Lysozyme L99A, identifying new ligands and confirming their binding through experimental methods.

bioRxiv · Apr 20, 2021Biophysics

In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization

P. Winter, S. Stubenvoll, S. Scheiblhofer, I. A. Joubert, L. Strasser, C. Briganser, W. T. Soh, F. Hofer, A. S. Kamenik, V. Dietrich, S. Michelini, J. Laimer, P. Lackner, J. Horejs-Hoeck, M. Tollinger, , R. Weiss

bioRxiv · Feb 26, 2020Immunology