J. Hicks

Marker Data Enhancement For Markerless Motion Capture

This paper improves motion capture accuracy by enhancing sparse keypoints with a more generalizable marker enhancer trained on a larger dataset.

Cells in the Polyaneuploid Cancer Cell State are Pro-Metastatic

This study shows that polyaneuploid cancer cells (PACCs) are pro-metastatic in vivo, based on in vitro and in vivo experiments in mouse models.

Self-Supervised Learning Improves Accuracy and Data Efficiency for IMU-Based Ground Reaction Force Estimation

This paper uses self-supervised learning to improve accuracy and reduce data requirements for estimating ground reaction forces from IMU data.

A role for the ATP-dependent DNA ligase Lig E of Neisseria gonorrhoeae in biofilm formation

This study shows that Lig E in Neisseria gonorrhoeae is non-essential for DNA repair but plays a role in biofilm formation and extracellular DNA joining.

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

Simulated musculoskeletal optimization for sprinting and marathon running

This study develops a differentiable musculoskeletal simulator to optimize sprinting and marathon running performance, revealing new insights into muscle distribution and hip musculature importance.

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

OpenSense: An open-source toolbox for Inertial-Measurement-Unit-based measurement of lower extremity kinematics over long durations

OpenSense estimates lower extremity joint kinematics from IMUs with accuracy comparable to optical motion capture and minimal drift over 10 minutes.

PHENOTYPIC CHARACTERIZATION OF TWO NOVEL CELL LINE MODELS OF CASTRATION RESISTANT PROSTATE CANCER.

This study develops two novel castration-resistant prostate cancer cell lines and characterizes their transcriptomic and proteomic profiles to understand resistance mechanisms.

P2X4 Purinergic Receptors as a Therapeutic Target in Aggressive Prostate Cancer

This study identifies P2X4 purinergic receptors as a driver of aggressive prostate cancer and a potential therapeutic target through in vitro and in vivo experiments.

Discovery of A New Class of Integrin Antibodies for Fibrosis

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

A Pentatricopeptide Repeat Protein in the Plasmodium apicoplast is essential and shows sequence-specific RNA binding

This study identifies and characterizes PPR1, an essential apicoplast-targeted PPR protein in Plasmodium that binds specific RNA sequences and protects transcripts from degradation.