J. M. Cook

Development of non-sedating antischistosomal benzodiazepines

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a beta-amyloid deposition model of Alzheimer's disease pathology

This study shows that GL-II-73, a 5-GABAAR positive allosteric modulator, improves cognitive function and neuronal structure in Alzheimer's disease models despite beta-amyloid accumulation.

Staying in touch: how highly specialised moth pollinators track host plant phenology in unpredictable climates

This study investigates how Epicephala moths synchronize their life cycle with the flowering of their host plant Breynia oblongifolia, finding evidence of diapause at multiple stages and a bet hedging strategy for adult emergence.

Low coverage genomic data resolve the population divergence and gene flow history of an Australian rain forest fig wasp

The paper uses low coverage genomic data to infer the divergence and gene flow history of an Australian rain forest fig wasp, finding strong support for an admixture model.

Non-sedating benzodiazepines cause contractile paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni

This study identifies non-sedating benzodiazepines that cause contractile paralysis and tissue damage in Schistosoma mansoni, offering potential for new anti-schistosomal drugs with reduced host side effects.

Illuminating the functional rare biosphere of the Greenland Ice Sheet’s Dark Zone

The paper analyzes microbial communities in the Greenland Ice Sheet’s Dark Zone using 16S rRNA gene and cDNA data to reveal the role of rare taxa in albedo reduction and melting.

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.