Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner
C. Sumi, A. Okamoto, H. Tanaka, K. Nishi, M. Kusunoki, T. Shoji, T. Uba, Y. Matsuo, T. Adachi, J.-I. Hayashi, K. Takenaga, K. Hirota
This study shows propofol causes metabolic reprogramming and cell death by impairing mitochondrial function, specifically complexes I and III, and this effect is exacerbated by preexisting mitochondrial dysfunction.
bioRxiv · Nov 16, 2017Pharmacology & Toxicology