A. Okamoto

Novel therapeutic strategies for injured endometrium: Autologous intrauterine transplantation of menstrual blood-derived cells from infertile patients

This study evaluates the therapeutic potential of menstrual blood-derived cells from infertile patients for injured endometrium, showing improved endometrial thickness and fertility outcomes in a mouse model.

Safety margin evaluations for transtympanic laser stimulation of the cochlea from the outer ear in Mongolian gerbils (Meriones unguiculatus)

This study evaluates the safety of prolonged laser stimulation on the cochlea in Mongolian gerbils, finding a safety margin at 6.6 W/cm2 but significant damage at 26.4 W/cm2 after 15 hours.

Chemoenzymatic fluorescence labeling of intercellularly contacting cells using lipidated sortase A

This study develops a method to selectively label intercellularly contacting cells using chemoenzymatic approaches, validated by microscopy and flow cytometry.

Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

The paper shows that glutamine deficiency in cancer cells prevents p53 activation by rRNA synthesis inhibitors, promoting survival during nutrient stress.

Deep learning generates custom-made logistic regression models for explaining how breast cancer subtypes are classified

The paper develops an explainable deep learning model to generate logistic regression models for breast cancer subtype classification, showing its utility in identifying gene-subtype relationships.

Basicity of N5 in semiquinone enhances the rate of respiratory electron outflow in Shewanella oneidensis MR-1

This study shows that the basicity of N5 in semiquinone cofactors enhances the rate of extracellular electron transport in Shewanella oneidensis MR-1 by facilitating protonation-dependent electron outflow.

Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner

This study shows propofol causes metabolic reprogramming and cell death by impairing mitochondrial function, specifically complexes I and III, and this effect is exacerbated by preexisting mitochondrial dysfunction.

Fetal therapy model of myelomeningocele with three-dimensional skin using amniotic fluid cell-derived induced pluripotent stem cells

This study uses iPSC-derived artificial skin to treat a rat model of myelomeningocele during pregnancy, showing potential for antenatal therapy.