Author

Ka Man Wu

Radboud University Nijmegen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:graph neural network· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Nael Nadif KasriiD· 4 shared Hans van BokhoveniD· 3 shared Dirk SchubertiD· 2 shared Elly LewerissaiD· 2 shared Naoki KogoiD· 2 shared Adelaide Maria Fernandes Borralho· 1 shared Alain Geille· 1 shared Albert Carbonell· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Nael Nadif KasriORCID

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Author profile →

4 papers

Recent·Most cited

KG-Bench: Benchmarking Graph Neural Network Algorithms for Drug Repurposing

Siqi Wei, Christo Sasi, Jelle Piepenbrock, Martijn A. Huynen, Peter A.C. ’t Hoen, Tessa Braam, Esther Bührman, Juliette Chevalier, Martina Cornelia Cornel, Lotte Haverman, Vivi Majella Heine, Annelieke R. Müller, Tessel Rigter, Tom Steenbergen, Clara van Karnebeek, , Sara Pintado

KG-Bench benchmarks graph neural networks for drug repurposing using the Open Targets dataset, finding TransformerConv achieves the highest performance.

Bioinformatics · May 7, 2026Peer-reviewedBioinformatics

Mapping NMD-coupled alternative splicing in iPSC-derived brain cells: a resource for therapeutic discovery

Kim N. Wijnant, Imke M. E. Schuurmans, Annika Mordelt, Ka Man Wu, Michael P. Kwint, Lisenka E.L.M. Vissers, Nael Nadif Kasri

The paper maps NMD-coupled alternative splicing events in iPSC-derived brain cells and identifies therapeutic targets for neurodevelopmental disorders.

bioRxiv · Jan 22, 2026 · PreprintGenetics

SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

Eline van Hugte, Elly Lewerissa, Ka Man Wu, Nicky Scheefhals, Giulia Parodi, Torben W. van Voorst, Sofia Puvogel, Naoki Kogo, Jason M. Keller, Monica Frega, Dirk Schubert, Helenius Jurgen Schelhaas, Judith S. Verhoeven, Marian Majoie, Hans van Bokhoven, Nael Nadif Kasri

This study investigates SCN1A mutations in excitatory neuronal networks derived from patient hiPSCs, revealing mutation-specific phenotypes that correlate with clinical outcomes and drug responses.

Brain · Jul 19, 2023Peer-reviewedNeuroscience

Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

Shan Wang, Jon-Ruben van Rhijn, Ibrahim A. Akkouh, Naoki Kogo, Nadine Maas, Anna Bleeck, Irene Santisteban Ortiz, Elly Lewerissa, Ka Man Wu, Chantal Schoenmaker, Srdjan Djurovic, Hans van Bokhoven, Tjitske Kleefstra, Nael Nadif Kasri, Dirk Schubert

This study shows that SETD1A loss-of-function mutations increase dendritic complexity and neuronal bursting in human neurons via a hyperactive cAMP/PKA pathway, which can be rescued by pharmacological intervention.

Cell Reports · May 1, 2022Peer-reviewedNeuroscience