George Larry Maxwell

Maternal and fetal HLA heterozygosity in preeclampsia: Insights from a large multi-ancestry pregnancy cohort

This study examines the association between maternal and fetal HLA heterozygosity and preeclampsia risk in a large multi-ancestry cohort, finding protective and risk associations for specific HLA loci.

ShapeUpLMD: An Automated Pipeline for Spatially Optimized Laser Microdissection in Multi-omic Tissue Profiling

ShapeUpLMD automates ROI optimization for laser microdissection, improving tumor purity and spatial accuracy in multi-omic tissue profiling.

ProteoMixture: A Cell Type Deconvolution Tool for Bulk Tissue Proteomics Data

ProteoMixture estimates cell type proportions in bulk tissue proteomics data using optimized protein signatures validated on high-grade serous ovarian cancer samples.

A modified dual preparatory method for improved isolation of nucleic acids from laser microdissected fresh-frozen human cancer tissue specimens

The paper describes a modified dual preparatory method to improve RNA yield from laser microdissected human cancer tissue samples.

A transgenerational mutational signature from ionizing radiation exposure.

This study finds that paternal exposure to ionizing radiation increases clustered de novo mutations in offspring, suggesting cDNMs as a transgenerational biomarker.

The relationships between genetic ancestry, somatic mutation frequency, and histologic subtypes in high-grade endometrial cancer

This study examines the relationship between genetic ancestry, somatic mutation frequency, and histologic subtypes in high-grade endometrial cancer, finding associations between local ancestry and tumor mutation burden and histologic subtypes.

Stochasticity explains differences in the number of de novo mutations between families

The paper investigates family-specific contributions to de novo mutations and finds that stochasticity explains most of the variation.