Author

Kendra Hoffsmith

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Nancy CarrascoiD· 2 shared Alejandra Paola Torres-ManzoiD· 1 shared Alejandro Llorente-Esteban· 1 shared Andrea Reyna‐NeyraiD· 1 shared Antonio Carlos BiancoiD· 1 shared David López-González· 1 shared Federico Salas-LuciaiD· 1 shared Geoffrey Winston AbbottiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Nancy CarrascoORCID

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2 papers

Recent·Most cited

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)

Alejandro Llorente-Esteban, Haswitha Sabbineni, Kendra Hoffsmith, Rían W. Manville, David López-González, Andrea Reyna‐Neyra, J. Alfonso Leyva, Geoffrey Winston Abbott, Mario A. Bianchet, Nancy Carrasco

This paper engineers a sodium/iodide symporter variant that selectively transports oxyanions over iodide, enabling targeted cancer therapy without harming the thyroid.

bioRxiv · Oct 7, 2025 · PreprintBiophysics

Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations

Jessica Rampy, Alejandra Paola Torres-Manzo, Kendra Hoffsmith, Matthew A. Loberg, Quanhu Sheng, Federico Salas-Lucia, Antonio Carlos Bianco, Rafael Arrojo e Drigo, Huiying Wang, Vivian Lee Weiss, Nancy Carrasco

This study shows overnutrition causes hypothyroidism in mice by impairing thyroid hormone biosynthesis and utilization, despite thyroid adaptations, and finds a link between BMI and thyroid vascularization in humans.

bioRxiv · Mar 31, 2025 · PreprintPhysiology