Kenneth D. Harris

AI-discovered tuning laws explain neuronal population code geometry

This paper uses AI to discover an equation explaining how neuronal tuning smoothness controls population code geometry in visual cortex and head-direction cells.

A Brain-Wide Map of Neural Activity during Complex Behaviour

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

A common computational and neural anomaly across mouse models of autism

The paper shows that mice with ASD-related mutations exhibit similar computational and neural anomalies in prior updating during decision-making.

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Mouse frontal cortex nonlinearly encodes sensory, choice and outcome signals

The paper shows that MOs neurons in mice encode task variables nonlinearly, particularly during decision-making, allowing linear decoding of behavior even in the absence of direct sensory input.

Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex

This study shows that learning a visuomotor task increases visual stimulus-evoked activity in the medial prefrontal cortex, even during passive viewing.

Task specificity in mouse parietal cortex

The paper shows that neurons in mouse parietal cortex are task-specific, with their activity determined by physical context rather than task content.

Neural basis of functional ultrasound signals

This study shows that functional ultrasound signals correlate with neural firing rates in awake mice, revealing a direct relationship between hemodynamic signals and neuronal activity.

Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration

This study shows that disrupting VGLUT1 in cholinergic medial habenula neurons increases nicotine self-administration, suggesting glutamate co-release opposes nicotine consumption.

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

The paper introduces Neuropixels 2.0, a high-density probe for long-term brain recordings, and demonstrates its stability across months in multiple labs and species.

Cortical state fluctuations during sensory decision making

This study investigates cortical state fluctuations during sensory decision making and finds that desynchronization correlates with task engagement rather than accuracy.

Modulation of visual cortex by hippocampal signals

This study shows that spatial representations in V1 and CA1 are correlated and influenced by non-visual factors like distance traveled and theta oscillations.

Equations governing dynamics of excitation and inhibition in the mouse corticothalamic network

The paper shows that mean-field models of cortical dynamics require inclusion of thalamic interactions to accurately predict responses to optogenetic stimulation in awake mice.

Retinal outputs depend on behavioural state

The paper shows that retinal outputs in mice are modulated by behavioural state, as observed in the superficial superior colliculus and optic tract, even in darkness.

Distributed correlates of visually-guided behavior across the mouse brain

The paper records neuronal activity across the mouse brain during a visual task and finds widespread activation and specific midbrain circuits involved in choice.

High-dimensional geometry of population responses in visual cortex

The paper analyzes the correlation structure of natural image coding in visual cortical populations of awake mice, finding a power-law decay in principal component variance that reflects coding smoothness.

Spontaneous behaviors drive multidimensional, brain-wide population activity

The paper shows that spontaneous brain activity encodes multidimensional behavioral information across the forebrain, alongside sensory input in orthogonal dimensions.

Coherent representations of subjective spatial position in primary visual cortex and hippocampus

The paper shows that visual responses in V1 and hippocampal CA1 encode the animal's subjective spatial position during navigation in virtual reality.

Molecular architecture of the mouse nervous system

The paper maps cell types in the mouse nervous system using single-cell RNA sequencing and identifies distinct astrocyte and oligodendrocyte subtypes with specific molecular and spatial characteristics.

Vision and locomotion shape the interactions between neuron types in mouse visual cortex

The paper examines how locomotion affects neuron interactions in mouse visual cortex, finding that it alters synaptic connectivity rather than just disinhibition.

High-yield methods for accurate two-alternative visual psychophysics in head-fixed mice

This paper introduces high-yield methods for two-alternative visual psychophysics in head-fixed mice, showing rapid learning and accurate psychometric curves.

Suite2p: beyond 10,000 neurons with standard two-photon microscopy

Suite2p processes two-photon calcium movies faster than real time on desktop workstations, roughly doubling curated cell yield over CNMF and recovering 13,451 neurons in one session.

Robustness of spike deconvolution for calcium imaging of neural spiking

This study compares spike deconvolution methods for calcium imaging and finds that non-negative deconvolution (NND) is the most accurate and efficient approach.

Subcortical source and modulation of the narrowband gamma oscillation in mouse visual cortex

The paper identifies the source and modulation factors of a narrowband gamma oscillation in mouse visual cortex, showing it is driven by thalamic input and suppressed by visual contrast.

Spike sorting for large, dense electrode arrays

The paper develops novel spike sorting tools for large, dense electrode arrays, achieving 5% error rates on rat cortex data.