Author

Kenneth J. Lim

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Approach:experimental assay· 2

Frequent Co-Authors

Alex S. NordiD· 5 shared John L.R. RubensteiniD· 3 shared Rinaldo Catta-PretaiD· 3 shared Athéna Rebecca YpsilantiiD· 2 shared Eirene Markenscoff-PapadimitriouiD· 2 shared Iva ZdilariD· 2 shared Linda Su-FeheriD· 2 shared Matthew W. StateiD· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersNeuroscience

Alex S. NordORCID

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Author profile →

5 papers

Recent·Most cited

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Siavash Fazel Darbandi, Joon‐Yong An, Kenneth J. Lim, Nicholas F. Page, Lindsay Liang, Athéna Rebecca Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S. Nord, Stephan Sanders, John L.R. Rubenstein

The paper identifies shared regulatory targets of autism-associated transcriptional regulators in brain-expressed genes and shows their functional convergence in neurodevelopmental outcomes.

bioRxiv · Oct 17, 2022 · PreprintGenomics

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

Eirene Markenscoff-Papadimitriou, Fadya Binyameen, Sean Whalen, James Price, Kenneth J. Lim, Athéna Rebecca Ypsilanti, Rinaldo Catta-Preta, Emily Ling-Lin Pai, Xin Ni Mu, Duan Xu, Katherine S. Pollard, Alex S. Nord, Matthew W. State, John L.R. Rubenstein

The paper shows POGZ promotes chromatin accessibility and expression of synaptic genes in mouse and human brains, and its reduction disrupts cortical function through interactions with ADNP.

Cell Reports · Dec 1, 2021Peer-reviewedNeuroscience

Parallel functional testing identifies enhancers active in early postnatal mouse brain

Jason T. Lambert, Linda Su-Feher, Karol Cichewicz, Tracy L. Warren, Iva Zdilar, Yurong Wang, Kenneth J. Lim, Jessica Haigh, Sarah J. Morse, César P. Canales, Tyler W. Stradleigh, Erika Castillo Palacios, Viktoria Haghani, Spencer D Moss, Hannah Parolini, , Alex S. Nord

The paper identifies and validates enhancers active in early postnatal mouse brain using a modified MPRA approach and rAAV delivery.

eLife · Oct 4, 2021Peer-reviewedNeuroscience

Single Cell Enhancer Activity Maps Neuronal Lineages in Embryonic Mouse Basal Ganglia

Linda Su-Feher, Anna Noren Rubin, Shanni N. Silberberg, Rinaldo Catta-Preta, Kenneth J. Lim, Iva Zdilar, Christopher S. McGinnis, Gabriel L. McKinsey, Thomas E. Rubino, Michael Hawrylycz, Carol L. Thompson, Zev J. Gartner, Luis Puelles, Hongkui Zeng, John L.R. Rubenstein, Alex S. Nord

The paper uses scRNA-seq and enhancer-based labeling to map neuronal lineages in embryonic mouse basal ganglia and identifies novel lineage specification paths.

bioRxiv · Jan 11, 2021 · PreprintNeuroscience

CHD8 Regulates Cellular Homeostasis and Neuronal Function Genes Across Multiple Models of CHD8 Haploinsufficiency

A. Ayanna Wade, Kenneth J. Lim, Rinaldo Catta-Preta, Alex S. Nord

This study identifies CHD8 as a critical regulator of gene expression by analyzing transcriptomic and epigenomic data from multiple CHD8 knockdown and knockout models, revealing high-affinity interactions with genes involved in cellular homeostasis and neuronal function.

bioRxiv · Jul 23, 2018 · PreprintNeuroscience