Emily Ling-Lin Pai

Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy

The paper shows that patient-derived glioblastoma organoids can reflect CAR-T cell treatment responses in real-time, correlating with clinical outcomes in patients.

A Spinal Circuit That Transmits Innocuous Cool Sensations

The paper identifies a spinal circuit that transmits innocuous cool sensations by characterizing a specific population of interneurons.

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

The paper shows POGZ promotes chromatin accessibility and expression of synaptic genes in mouse and human brains, and its reduction disrupts cortical function through interactions with ADNP.

Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons

This study shows that Nf1 deletion causes loss of parvalbumin+ cortical interneurons and reduces Lhx6 expression, affecting their development.

The Tuberous Sclerosis gene, Tsc1, represses parvalbumin+/fast-spiking properties in somatostatin-lineage cortical interneurons

This study shows that loss of Tsc1 leads to PV expression and fast-spiking properties in SST+ cortical interneurons, reversible by rapamycin.