Author

Kerstin C. Maier

Max Planck Institute for Biophysical Chemistry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:machine learning (classical)· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Kristina ŽumeriD· 2 shared Patrick CrameriD· 2 shared Achim TreschiD· 1 shared Björn SchwalbiD· 1 shared Christopher BattersiD· 1 shared Jana SchmitzováiD· 1 shared Jason M. Müller· 1 shared Julien GagneuriD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMolecular Biology

Kristina ŽumerORCID

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4 papers

Recent·Most cited

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

Luojia Zhang, Christopher Batters, Shintaro Aibara, Yuliya Gordiyenko, Kristina Žumer, Jana Schmitzová, Kerstin C. Maier, Patrick Cramer, Suyang Zhang

The paper reports the cryo-EM structure of a transcribing Pol II-U1 snRNP complex with DSIF and SPT6, showing how phosphorylated Pol II and SPT6 interact with U1 snRNP to facilitate spliceosome assembly and transcription processivity.

Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology

Nuclear export is a limiting factor in eukaryotic mRNA metabolism

Jason M. Müller, Katharina Moos, Till Baar, Kerstin C. Maier, Kristina Žumer, Achim Tresch

This study quantifies mRNA synthesis, nuclear export, and degradation rates genome-wide, finding nuclear export is slow and cytosolic degradation is fast, with some transcripts using alternative export pathways.

PLoS Computational Biology · May 16, 2024Peer-reviewedSystems Biology

Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms

Kerstin C. Maier, Saskia Gressel, Patrick Cramer, Björn Schwalb

The paper introduces nano-ID, a method using nanopore sequencing and machine learning to study RNA isoform synthesis and stability, revealing differences in metabolism between individual isoforms and gene-level estimates.

bioRxiv · May 11, 2019Molecular Biology

Cis-regulatory elements explain most of the mRNA stability variation across genes in yeast

Jun Cheng, Kerstin C. Maier, Žiga Avsec, Petra Rus, Julien Gagneur

This study quantifies how mRNA sequence features influence stability in yeast, revealing key motifs and dependencies on degradation pathways.

RNA · Aug 11, 2017Peer-reviewedGenomics