A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity
Yuqing Wang, Khashayar Afshari, Nazgol‐Sadat Haddadi, Carolina S. Lopes, Chee-Huat Linus Eng, Leah M. Whiteman, Nuria Martinez, Pyae Phyo Kyawe, Ksenia S. Anufrieva, Kevin Wei, Kirsten L. Frieda, Misha A. Rosenbach, Ruth Ann Vleugels, Stefania Gallucci, John E. Harris, , Manuel G. Garber
This study identifies MMP9+ CD14+ myeloid cells as key drivers of UVB-induced IFN-I-driven inflammation in cutaneous lupus and dermatomyositis through a keratinocyte-fibroblast-myeloid circuit.
Nature Immunology · Apr 24, 2026Peer-reviewedImmunology