Author

Ruth Ann Vleugels

Brigham and Women's HospitalORCID 0000-0001-8446-7115Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Kevin WeiiD· 2 shared Khashayar AfshariiD· 2 shared Ksenia S. AnufrievaiD· 2 shared Mehdi RashighiiD· 2 shared A. Maeda· 1 shared Akiko Shimazaki-Takahashi· 1 shared Anastasia N. KazakovaiD· 1 shared Antonella NotarnicolaiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Kevin WeiORCID

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Author profile →

3 papers

Recent·Most cited

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

T. Hsu, Xi Wang, Jiayan Zhang, Yukari Isayama, Viktoria E. M. Schindler, Eveline Van Gompel, Hadil Maadadi, Celia Torres-Arancivia, Akiko Shimazaki-Takahashi, Nina Kurihara, Mariko Kondo, Marina Galesic, Antonella Notarnicola, Sharmin Sultana, A. Maeda, , Sun Hur

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

bioRxiv · Jul 31, 2026 · PreprintBiochemistry✦ In-depth digest

Spatial Transcriptomics Identifies Immune-Stromal Niches Associated with Cancer in Adult Dermatomyositis

Ksenia S. Anufrieva, Neda Shahriari, Ce Gao, Stephanie Pei Tung Yiu, Shideh Kazerounian, Rochelle L. Castillo, Jessica Liu, Sean A. Prell, Kartik Bhamidipati, Khashayar Afshari, Lindsay Parmelee, Anastasia N. Kazakova, Erin Theisen, Teresa Venezia Bowman, Avery LaChance, , Kevin Wei

This study uses spatial and single-cell transcriptomics to identify immune-stromal niches in adult-onset dermatomyositis, revealing distinct cellular and cytokine signatures associated with cancer and non-cancer lesions.

Nature Communications · Jun 26, 2026Peer-reviewedImmunology

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity

Yuqing Wang, Khashayar Afshari, Nazgol‐Sadat Haddadi, Carolina S. Lopes, Chee-Huat Linus Eng, Leah M. Whiteman, Nuria Martinez, Pyae Phyo Kyawe, Ksenia S. Anufrieva, Kevin Wei, Kirsten L. Frieda, Misha A. Rosenbach, Ruth Ann Vleugels, Stefania Gallucci, John E. Harris, , Manuel G. Garber

This study identifies MMP9+ CD14+ myeloid cells as key drivers of UVB-induced IFN-I-driven inflammation in cutaneous lupus and dermatomyositis through a keratinocyte-fibroblast-myeloid circuit.

Nature Immunology · Apr 24, 2026Peer-reviewedImmunology