Author

Pyae Phyo Kyawe

University of Massachusetts Chan Medical SchoolORCID 0000-0002-8259-6017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Carolina S. Lopes· 1 shared Chee-Huat Linus Eng· 1 shared Evan Stuart BradleyiD· 1 shared Jennifer P WangiD· 1 shared John E. HarrisiD· 1 shared Katherine A. FitzgeraldiD· 1 shared Kevin WeiiD· 1 shared Khashayar AfshariiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Carolina S. Lopes

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity

Yuqing Wang, Khashayar Afshari, Nazgol‐Sadat Haddadi, Carolina S. Lopes, Chee-Huat Linus Eng, Leah M. Whiteman, Nuria Martinez, Pyae Phyo Kyawe, Ksenia S. Anufrieva, Kevin Wei, Kirsten L. Frieda, Misha A. Rosenbach, Ruth Ann Vleugels, Stefania Gallucci, John E. Harris, , Manuel G. Garber

This study identifies MMP9+ CD14+ myeloid cells as key drivers of UVB-induced IFN-I-driven inflammation in cutaneous lupus and dermatomyositis through a keratinocyte-fibroblast-myeloid circuit.

Nature Immunology · Apr 24, 2026Peer-reviewedImmunology

CRISPR editing of candidate host factors that impact influenza A virus infection

Pyae Phyo Kyawe, Ping Liu, Zhaozhao Jiang, Evan Stuart Bradley, Thomas Cicuto, Melanie I. Trombly, Neal S. Silverman, Katherine A. Fitzgerald, William M. McDougall, Jennifer P Wang

This paper uses CRISPR to test host factors affecting influenza A virus infection, finding that CMAS knockout and B4GALNT2 overexpression restrict IAV, while ADAR1 overexpression has a pro-viral effect on CVB.

Microbiology Spectrum · Jan 31, 2025Peer-reviewedImmunology