Ulf Andersson Ørom

Fine-tuning m6A and METTL3 levels have profound impact on cellular proliferation and protein synthesis

The paper shows that altering m6A and METTL3 levels affects cellular proliferation and protein synthesis in TNBC cells.

N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules

This study shows that N4-acetylcytidine (ac4C) on mRNA promotes localization of transcripts and proteins to stress granules, regulating translation and stress response.

m6A RNA modification of mHtt intron 1 regulates the generation of Htt1a in Huntington's Disease

This study investigates how m6A RNA modifications in Htt intron 1 regulate the production of the pathogenic Htt1a transcript in Huntington's Disease.

Identification and prediction of G-quadruplex RNA-binding proteins with roles in transcription and phase separation

The paper identifies and predicts RNA G-quadruplex-binding proteins, showing their roles in transcription and phase separation, and provides a web tool for prediction.

Nuclear RNA-acetylation can be erased by the deacetylase SIRT7

The paper identifies NOP58 as a reader and SIRT7 as an eraser of the RNA acetylation ac4C, showing SIRT7 can deacetylate RNA in vitro and affecting snoRNA function and pre-rRNA processing.

SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency

SPLICE-q quantifies splicing efficiency using RNA-seq data and is applied to yeast, human nascent RNA-seq, and prostate cancer samples.

Determination of primary microRNA processing in clinicalsamples by targeted pri-miR-sequencing

This paper presents a high-sensitivity targeted method to measure pri-miRNA processing efficiency in clinical samples and identifies 24 microRNAs with significant changes in processing efficiency between normal liver and hepatocellular carcinoma.

Transient N-6-methyladensosine Transcriptome sequencing reveals a regulatory role of m6A in splicing efficiency

The paper investigates the role of m6A in splicing efficiency by analyzing nascent RNA transcripts and shows that early m6A deposition accelerates splicing.

Chromatin-release of the long ncRNA A-ROD is required for transcriptional activation of its target gene DKK1

The paper identifies A-ROD as a long ncRNA that requires chromatin-release to activate DKK1 transcription by recruiting EBP1 to the promoter.

Microprocessor dynamics shows co- and post-transcriptional processingof pri-miRNAs

The paper develops a method to study pri-miRNA processing kinetics in vivo and shows co- and post-transcriptional processing occurs with varying speeds.