Author

J. R. Ferdinand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Physiology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Organism:human· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

M. R. Clatworthy· 7 shared K. B. Meyer· 3 shared S. A. Teichmann· 3 shared E. Stephenson· 2 shared K. Polanski· 2 shared K. Saeb-Parsy· 2 shared M. Haniffa· 2 shared Z. K. Tuong· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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7 shared papersImmunology

M. R. Clatworthy

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7 papers

Recent·Most cited

Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge

M. L. Coates, N. Richoz, Z. K. Tuong, G. Bowyer, C. Y. C. Lee, J. R. Ferdinand, E. Gillman, M. McClure, R. Di Marco Barros, B. J. Stewart, M. R. Clatworthy

This study examines immune responses in human nasal-associated lymphoid tissue after SARS-CoV-2 infection, revealing coordinated defense mechanisms involving monocytes, macrophages, B cells, and T cells.

bioRxiv · Sep 15, 2023 · PreprintImmunology

Obesity associated with attenuated tissue immune cell responses in COVID-19

S. A. Guo, G. S. Bowyer, J. R. Ferdinand, M. Maes, Z. K. Tuong, E. Gilman, M. Liao, R. G. H. Lindeboom, M. Yoshida, K. Worlock, H. Gopee, E. Stephenson, P. A. Lyons, K. G. C. Smith, M. Haniffa, , M. R. Clatworthy

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Memory-like B cells emerging from germinal centres recycle through the subcapsular sinus

Y. Zhang, L. Garcia-Ibanez, C. Ulbricht, L. S. C. Lok, T. W. Dennison, J. R. Ferdinand, J. Mueller-Winkler, C. J. M. Burnett, J. C. Yam-Puc, L. Zhang, G. Brown, V. Tybulewicz, A. Rot, A. E. Hauser, M. R. Clatworthy, K.-M. Toellner

The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.

bioRxiv · Dec 8, 2020 · PreprintImmunology

A cell atlas of human thymic development defines T cell repertoire formation

J.-E. Park, R. A. Botting, C. Dominguez Conde, D.-M. Popescu, M. Lavaert, D. J. Kunz, E. Stephenson, R. Ragazzini, E. Tuck, A. L. Wilbrey-Clark, J. R. Ferdinand, S. Webb, D. Maunder, N. Vandamme, K. T. Mahbubani, , S. A. Teichmann

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

bioRxiv · Jan 28, 2020Immunology

Distinct microbial and immune niches of the human colon

K. R. James, T. Gomes, R. Elmentaite, N. Kumar, E. L. Gulliver, H. W. King, M. D. Stares, B. R. Bareham, J. R. Ferdinand, V. Petrova, K. Polanski, S. C. Forster, L. B. Jarvis, O. Suchanek, S. Howlett, , S. A. Teichmann

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

bioRxiv · Dec 12, 2019Immunology

Transcriptional analysis identifies novel biomarkers associated with successful ex-vivo perfusion of human donor lungs

J. R. Ferdinand, M. I. Morrison, A. Andreasson, C. Charlton, A. Chhatwal, W. E. Scott, L. A. Borthwick, M. R. Clatworthy, A. J. Fisher

Transcriptional analysis of lungs during ex-vivo perfusion identifies CHIT1 and SCGB1A1 as potential biomarkers to distinguish transplantable from non-transplantable lungs.

bioRxiv · Apr 17, 2019 · PreprintPhysiology

Investigation of the transcriptional profile of human kidneys during machine perfusion reveals potential benefits of haemoadsorption

J. R. Ferdinand, S. A. Hosgood, T. Moore, C. J. Ward, T. Castro Dopico, M. L. Nicholson, M. R. Clatworthy

The study compares cold storage and normothermic machine perfusion (NMP) on kidney transcriptomes, showing haemoadsorption reduces inflammation and enhances energy metabolism.

bioRxiv · Jan 16, 2019 · PreprintPhysiology