M. R. Clatworthy

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

This study examines immune responses in human nasal-associated lymphoid tissue after SARS-CoV-2 infection, revealing coordinated defense mechanisms involving monocytes, macrophages, B cells, and T cells.

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

Dandelion improves V(D)J analysis in scVDJ-seq data, enabling better lineage commitment predictions and insights into lymphocyte development.

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

Transcriptional analysis of lungs during ex-vivo perfusion identifies CHIT1 and SCGB1A1 as potential biomarkers to distinguish transplantable from non-transplantable lungs.

This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.