Author

L. A. Martinez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Ghosh· 2 shared S. Saha· 2 shared A. C. Soupir· 1 shared A. E. Berglund· 1 shared A. Parrales· 1 shared A. W. M. van der Velden· 1 shared B. J. Manley· 1 shared B. L. Fridley· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

M. Ghosh

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3 papers

Recent·Most cited

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology

p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression

M. Ghosh, S. Saha, J. Li, D. C. Montrose, L. A. Martinez

This study shows p53 suppresses tumors by promoting TREX1 degradation, leading to cytosolic DNA accumulation and activation of the cGAS/STING pathway, which induces type I interferons.

bioRxiv · May 26, 2022Cancer Biology

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

M. Ghosh, S. Saha, J. A. Bettke, R. Nagar, A. Parrales, T. Iwakuma, A. W. M. van der Velden, L. A. Martinez

This study identifies mtp53's role in suppressing innate immune signaling by inhibiting TBK1, promoting tumorigenesis through immune evasion.

bioRxiv · Mar 12, 2020Cancer Biology