Author

Y. C. Jang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 7 Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:cell-cell communication· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

M. Mohiuddin· 6 shared J. J. Choi· 5 shared S. E. Anderson· 5 shared W. M. Han· 5 shared N. H. Lee· 4 shared C. A. Aguilar· 3 shared A. J. Garcia· 2 shared B. Aliya· 2 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersCell Biology

M. Mohiuddin

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Author profile →

7 papers

Recent·Most cited

Identifying dysregulated immune cell subsets following critical volumetric muscle loss with pseudo-time trajectories

L. A. Hymel, S. E. Anderson, T. C. Turner, W. Y. York, H. S. Lim, P. Qiu, Y. C. Jang, N. J. Willett, E. A. Botchwey

The paper uses pseudo-time analysis to identify immune cell subset dysregulation in critical versus subcritical volumetric muscle loss in mice.

bioRxiv · May 25, 2021Immunology

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular Junction

P. J. Ulintz, J. Larouche, M. Mohiuddin, J. Castor Macias, S. J. Kurpiers, W. Liu, J. J. Choi, L. A. Brown, J. F. Markworth, K. de Silva, B. D. Levi, S. D. Merajver, J. V. Chakkalakal, Y. C. Jang, S. V. Brooks, C. A. Aguilar

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

bioRxiv · May 28, 2020Cell Biology

Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

J. J. Choi, E. J. Shin, W. M. Han, S. E. Anderson, M. Mohiuddin, N. H. Lee, T. Tran, S. Nakhai, H. Jeong, A. Shcherbina, G. Jeong, D. G. Oh, L. Weinstock, S. B. Sankar, M. E. Ogle, , Y. C. Jang

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

bioRxiv · May 24, 2020 · PreprintCell Biology

Transplantation of muscle stem cell mitochondria rejuvenates the bioenergetic function of dystrophic muscle

M. Mohiuddin, J. J. Choi, N. H. Lee, H. H. Jeong, S. E. Anderson, W. M. Han, B. Aliya, T. Z. Peykova, S. Verma, A. J. Garcia, C. A. Aguilar, Y. C. Jang

This study shows that transplanting healthy muscle stem cells into dystrophic muscle improves mitochondrial function and bioenergetics, while compromised stem cells fail to do so.

bioRxiv · Apr 17, 2020 · PreprintCell Biology

Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

Y. Lee, J. J. Choi, S. I. Ahn, N. H. Lee, W. M. Han, M. Mohiuddin, E. J. Shin, L. B. Wood, K. D. Park, Y. Kim, Y. C. Jang

This study develops an in vitro muscle parabiosis system to identify rejuvenating factors in aged muscle stem cells by mimicking systemic and local signals.

bioRxiv · Mar 10, 2020Cell Biology

Wnt7a-releasing synthetic hydrogel enhances local skeletal muscle regeneration and muscle stem cell engraftment

W. M. Han, M. Mohiuddin, S. E. Anderson, A. J. Garcia, Y. C. Jang

This paper develops a Wnt7a-releasing hydrogel to enhance skeletal muscle regeneration and stem cell engraftment in injured muscles.

bioRxiv · Mar 6, 2019Bioengineering

Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit and Myonuclear- and Mitochondrial-Domains

M. Mohiuddin, N. H. Lee, J. Y. Moon, W. M. Han, S. E. Anderson, J. J. Choi, S. Nakhai, T. Tran, B. Aliya, D. Y. Kim, A. Gerold, L. Hansen, W. R. Taylor, Y. C. Jang

This study investigates how critical limb ischemia affects skeletal muscle by increasing myonuclear number and mitochondrial content per myonucleus in mice.

bioRxiv · Sep 25, 2018Physiology