Author

D. S. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. J. Combes· 2 shared A. Ward· 2 shared B. Coventry· 2 shared D. J. Erle· 2 shared D. W. Hwang· 2 shared G. K. Fragiadakis· 2 shared H. Kim· 2 shared K. Kangelaris· 2 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

A. J. Combes

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Design of High Affinity Binders to Convex Protein Target Sites

D. Baker, W. Yang, D. R. Hicks, A. Ghosh, T. A. Schwartze, B. Coventry, I. Goreshnik, A. Allen, S. Halabiya, C. Kim, C. S. Hinck, D. S. Lee, A. Bera, Z. Li, Y. Wang, , A. P. Hinck

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

bioRxiv · May 1, 2024 · PreprintBiochemistry

De novo design of protein minibinder agonists of TLR3

C. S. Adams, H. Kim, A. E. Burtner, D. S. Lee, C. Dobbins, C. Criswell, B. Coventry, H. M. Kim, N. P. King

This study designs protein minibinders that act as agonists for TLR3, showing nanomolar binding and biological activity in cell lines.

bioRxiv · Apr 17, 2024Biochemistry

Age related susceptibility to grey matter demyelination and neurodegeneration is associated with meningeal neutrophil accumulation in an animal model of Multiple Sclerosis

M. Zuo, N. Fettig, L.-P. Bernier, E. Possnecker, S. Spring, A. Pu, X. I. Ma, D. S. Lee, L. Ward, A. Sharma, J. Kuhle, J. G. Sled, A.-K. Probstel, B. A. MacVicar, L. C. Osborne, , V. Ramaglia

The paper shows that age-related grey matter demyelination and neurodegeneration in MS are linked to meningeal neutrophil accumulation in an animal model.

bioRxiv · Dec 23, 2021 · PreprintImmunology

The Arabidopsis ORA59 coordinates jasmonic acid- and ethylene-responsive gene expression to regulate plant immunity

Y. N. Yang, Y. Kim, H. Kim, S. J. Kim, K.-M. Cho, Y. Kim, D. S. Lee, M.-H. Lee, S. Y. Kim, J. C. Hong, S. J. Kwon, J. Choi, O. K. Park

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

bioRxiv · Mar 16, 2021 · PreprintPlant Biology

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

M. G. P. van der Wijst, S. E. Vazquez, G. C. Hartoularos, P. Bastard, T. Grant, R. Bueno, D. S. Lee, J. R. Greenland, Y. Sun, R. Perez, A. Ogorodnikov, A. Ward, S. A. Mann, K. L. Lynch, C. Yun, , C. R. Langelier

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

bioRxiv · Mar 9, 2021 · PreprintImmunology

Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

S. Y. Kang, E. J. Lee, J. W. Byun, D. Han, Y. Choi, D. W. Hwang, D. S. Lee

This study shows that extracellular vesicles from highly glycolytic breast cancer cells induce an aggressive phenotype in low glycolytic luminal breast cancer cells via PKM2 phosphorylation.

bioRxiv · Feb 8, 2021 · PreprintCancer Biology

Discovery of μ,δ-Opioid receptor dual biased agonists that overcome the limitation of prior biased agonists

J. H. Lee, S.-Y. Shon, W. Jeon, S.-J. Hong, J. Ban, D. S. LEE

The paper identifies three dual biased agonists for mu and delta opioid receptors that show improved efficacy compared to existing biased agonists like Oliceridine.

bioRxiv · Jan 21, 2021Pharmacology & Toxicology

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

A. J. Combes, T. Courau, N. F. Kuhn, K. H. Hu, A. Ray, W. S. Chen, S. J. Clearly, N. W. Chew, D. Kushnoor, G. C. Reeder, A. Shen, J. Tsui, K. J. Hiam-Galvez, P. Munoz-Sandoval, W. S. Zhu, , M. F. Krummel

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

bioRxiv · Oct 28, 2020Immunology

Graphene-oxide quenching-based molecular beacon imaging of exosome-mediated transfer of neurogenic miR-193a on microfluidic platform

H. J. Oh, H. Park, D. Yoon, S. Chung, D. W. Hwang, D. S. Lee

The paper develops a molecular beacon imaging method using graphene-oxide quenching to visualize miR-193a transfer via exosomes during neurogenesis on a microfluidic platform.

bioRxiv · Jan 25, 2018Cell Biology