L. Haynes

Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression

This study uses single-cell transcriptomics to analyze EBV lytic reactivation in B cells, revealing abortive, reprogrammed, and host shutoff states with distinct gene expression patterns.

Investigating the phylogenetic history of toxin tolerance in mushroom-feeding Drosophila

This study investigates the evolution of cyclopeptide tolerance in mushroom-feeding Drosophila by combining phylogenetic analysis and functional assays, revealing that tolerance was ancestral and lost multiple times.

Cellular Senescence is a Double-Edged Sword in Regulating Aged Immune Responses to Influenza

This study shows that removing senescent cells in aged mice improves viral clearance but reduces immune memory formation after influenza infection.

An Essential Role of UBXN3B in B Lymphopoiesis

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections

This paper develops a multi-phenotype system to identify compounds that rejuvenate the immune response in older adults to viral infections, finding disulfiram and triptonide as promising candidates.

Lysosome exocytosis is required for mitosis

This study shows that lysosome exocytosis at telophase is essential for mitosis, as its inhibition causes mitotic failure.

Variation in the microbiome of the urogenital tract of koalas (Phascolarctos cinereus) with and without "wet bottom"

This study analyzes the urogenital tract microbiome of koalas with and without wet bottom using 16S rRNA sequencing to identify potential causative agents beyond Chlamydia pecorum.