K. Huber

Spatial patterns of Hyalomma marginatum-borne pathogens in the Occitanie region (France), a focus on the intriguing dynamics of Rickettsia aeschlimannii

The paper analyzes spatial patterns of pathogens in Hyalomma marginatum ticks in France, finding high infection rates of Rickettsia aeschlimannii with significant spatial variation.

A deterministic, c-di-GMP-dependent genetic program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

This study shows lipid overload activates E2F transcription factors in biliary epithelial cells, driving cell cycle progression and glycolytic metabolism to initiate ductular reaction without epithelial damage.

CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen related receptor (ERR)driven oxidative metabolism in skeletal muscle

This study shows that CDK4 deletion in mice improves endurance and reduces fat accumulation by enhancing ERR-driven oxidative metabolism in skeletal muscle.

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

The paper corrects for artifactual post-harvest metabolism in subcellular isotope tracing to reveal compartment-specific metabolic kinetics.