Author

H. L. Pepper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

N. W. Snyder· 2 shared A. A. Sims· 1 shared A. Bostwick· 1 shared A. U. Gurkar· 1 shared C. D. Lovell· 1 shared C. Mesaros· 1 shared E. Siefken· 1 shared E. von Krusenstiern· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

N. W. Snyder

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2 papers

Recent·Most cited

Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60.

S. Hamsanathan, T. Anthonymuthu, S. J. Mullet, S. Han, H. Shinglot, E. Siefken, A. A. Sims, P. Sen, H. L. Pepper, S. G. Wendell, N. W. Snyder, H. Bayir, V. E. Kagan, A. U. Gurkar

This study shows persistent DNA damage alters lipid metabolism and histone acetylation via MYS-1/Tip60, leading to immune-like responses and age-related decline.

bioRxiv · Jun 24, 2021Cell Biology

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

S. Trefely, K. Huber, J. Liu, M. Noji, S. Stransky, J. Singh, M. Doan, C. D. Lovell, E. von Krusenstiern, H. Jiang, A. Bostwick, H. L. Pepper, L. Izzo, S. Zhao, J. P. Xu, , N. W. Snyder

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

bioRxiv · Jul 30, 2020 · PreprintBiochemistry