Author

L. M. D'Cruz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. B. Frias· 2 shared B. Xie· 2 shared M. J. Jurczak· 2 shared A. C. Poholek· 1 shared A. L. Szymczak-Workman· 1 shared A. N. Fooks· 1 shared A. Piccirillo· 1 shared E. J. Hyzny· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

A. B. Frias

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 14, 2019

Blimp-1 in adipose resident Tregs controls adipocyte beiging and obesity

L. Y. Beppu, X. Qu, G. J. Marrero…·L. M. D'Cruz

This study shows that Blimp-1 in adipose Tregs suppresses IL-10, reducing beiging and increasing obesity risk, while its ablation improves insulin sensitivity and reduces weight in mice.

DOI 10.1101/2019.12.14.874693

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologybioRxivMar 27, 2019

The transcriptional regulator Id2 is critical for adipose-resident regulatory T cell differentiation, survival and function

A. B. Frias, E. J. Hyzny, H. M. Buechel…·L. M. D'Cruz

This study shows that Id2 is essential for the differentiation, survival, and function of adipose-resident regulatory T cells, and its loss leads to systemic inflammation and metabolic issues.

DOI 10.4049/jimmunol.1900358

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivNov 6, 2017

PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt

U. Uche, A. L. Szymczak-Workman, S. Grebinoski…·L. P. Kane

This study identifies TrIP as a negative regulator of T cell activation by inhibiting PI3K, showing its role in immune response and potential as a therapeutic target.

DOI 10.1084/jem.20172018

mouseexperimental assay

𝕏 PostBluesky